Реакция #7595

Уравнение реакции

4-chloro-6,7-dimethoxycinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline

Растворители

2-pentanol

Условия реакции

Обработка

1. 1
   Другое(prepared
2. 2
   ТемператураAfter cooling
3. 3
   Фильтрацияthe solid was filtered off
4. 4
   Промывкаwashed with isopropanol and ether
5. 5
   Другоеdried under vacuum

Методика

A solution of 4-chloro-6,7-dimethoxycinnoline hydrochloride (261 mg, 1 mmol), (prepared as described for the starting material in Example 1), and 2-fluoro-5-hydroxy-4-methylaniline (170 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (5 ml) was heated at 120° C. for 3 hours. After cooling, the solid was filtered off, washed with isopropanol and ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline as an hydrochloride salt (301 mg, 82%).

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