Реакция #7588

Уравнение реакции

4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride

Выход 29.3%

Растворители

2-pentanol

Условия реакции

Обработка

1. 1
   Другое(prepared
2. 2
   Температураwas heated
3. 3
   Температураat reflux for 4 hours
4. 4
   ФильтрацияAfter dilution with isopropanol the solid was filtered off
5. 5
   Промывкаwashed with isopropanol

Методика

A solution of 4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride (268 mg, 0.71 mmol), (prepared as described for the starting material in Example 10), and 2-fluoro-5-hydroxy-4-methylaniline, (109 mg, 0.77 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (6 ml) was heated at reflux for 4 hours. After dilution with isopropanol the solid was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride (92 mg, 29%).

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