Реакция #7577

Уравнение реакции

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

Выход 47.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 4 hours
3. 3
   Температураto cool
4. 4
   Экстракцияextracted with ethyl acetate (100 ml)
5. 5
   ЭкстракцияThe ethyl acetate extract
6. 6
   Сушкаwas dried (MgSO4)
7. 7
   Другоеthe solvent removed by evaporation

Методика

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

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