Реакция #75607

Уравнение реакции

sodium hydroxide

4-piperidinecarboxamide

benzyl chloride

potassium carbonate

→

1-benzyl-4-piperidine carboxamide

Выход 49.7%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеwas returned to room temperature
2. 2
   Экстракцияit was extracted with ethyl acetate
3. 3
   ПромывкаThe organic layer was washed with brine
4. 4
   Сушкаdried over anhydrous sodium sulfate
5. 5
   Другоеevaporated
6. 6
   ПромывкаThe resulting crystalline residue was washed with hexane/ethyl acetate
7. 7
   Фильтрацияcollected by filtration

Методика

A mixture of 15 g 4-piperidinecarboxamide, 16.3 g benzyl chloride, 32.3 g potassium carbonate and 200 ml N,N-dimethylformamide was stirred at 80° C. for 4 hr. The reaction solution was returned to room temperature, and aqueous sodium hydroxide was added thereto, and then it was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and then evaporated. The resulting crystalline residue was washed with hexane/ethyl acetate and collected by filtration. 12.7 g of 1-benzyl-4-piperidine carboxamide was obtained as white flaky crystals.

Источник