Реакция #75567

Уравнение реакции

2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-chloro-dithiobenzoic acid ethyl ester

trans-1,2 diaminocyclohexane

HCl

→

product

2-{2[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-chloro-phenyl}-3a,4,5,6,7,7a-hexahydro-1H-benzoimidazole

Растворители

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with methylene chloride twice
2. 2
   ПромывкаThe organic extracts were washed with brine
3. 3
   Сушкаdried (MgSO4)
4. 4
   Другоеevaporated
5. 5
   ДругоеThe residue was chromatographed on silica gel (eluting with 95:5 CH2Cl2/methanol)
6. 6
   Другоеto give a yellow oil
7. 7
   Другоеevaporated

Методика

As shown in Scheme 12, a solution of 187 mg (0.43 mmol) of 2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-chloro-dithiobenzoic acid ethyl ester in 2.5 mL of trans-1,2 diaminocyclohexane was heated to 110° C. in a sealed pressure tube for 12 hours. The reaction mixture was diluted with water and extracted with methylene chloride twice. The organic extracts were washed with brine, dried (MgSO4) and evaporated. The residue was chromatographed on silica gel (eluting with 95:5 CH2Cl2/methanol) to give a yellow oil. The oil was treated with methanolic HCl and evaporated to yield 34 mg of product as a pure hydrochloride salt.

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