Реакция #7527

Уравнение реакции

2-chloro-4-methoxybenzyl alcohol

triethylamine

methanesulfonyl chloride

→

title compound

Выход 61.0%

2-chloro-4-methoxybenzyl chloride

Выход 61.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe obtained residue was dissolved in ethyl acetate
3. 3
   ПромывкаThe organic layer was washed with saturated brine
4. 4
   Сушкаdried over anhydrous sodium sulfate
5. 5
   ДругоеThe solvent was evaporated under reduced pressure

Методика

To a solution of 2-chloro-4-methoxybenzyl alcohol (1.5 g, 8.7 mmol) in dichloromethane (10 mL) were added under ice-cooling triethylamine (2.4 mL, 17.4 mmol) and methanesulfonyl chloride (0.74 mL, 9.5 mmol) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.01 g, 61%).

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