Реакция #75170

Уравнение реакции

1-bromo-3-chloropropane

6-fluoro-1,3-dihydro-1-(1-methyl-2-phenylethenyl)-2H-benzimidazol-2-one

sodium hydroxide

→

1-(3-chloropropyl)-5-fluoro-1,3-dihydro-3-(1-methyl-2-phenylethenyl)-2H-benzimidazol-2-one

Выход 100.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеslightly exothermic reaction)
2. 2
   workup.STIRRINGUpon completion, stirring
3. 3
   ТемператураThe reaction mixture is cooled
4. 4
   Экстракцияthe product is extracted with methylbenzene
5. 5
   ДругоеThe extract is dried
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated

Методика

To a stirred and hot (50° C.) mixture of 15 parts of 6-fluoro-1,3-dihydro-1-(1-methyl-2-phenylethenyl)-2H-benzimidazol-2-one, 3 parts of N,N,N-triethylbenzenemethanaminium chloride and 75 parts of a sodium hydroxide solution 60% are added dropwise 11.1 parts of 1-bromo-3-chloropropane (slightly exothermic reaction). Upon completion, stirring is continued for 4 hours at 60° C. The reaction mixture is cooled, water is added and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 20 parts (100%) of 1-(3-chloropropyl)-5-fluoro-1,3-dihydro-3-(1-methyl-2-phenylethenyl)-2H-benzimidazol-2-one as an oily residue.

Источник