Реакция #75165

Уравнение реакции

1-(3-chloropropyl)-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one

4-(4-chlorophenyl)-4-piperidinol

sodium carbonate

potassium iodide

→

1-{3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl}-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one hydrochloride

Растворители

4-methyl-2-pentanone

water

water

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Другоеthe layers are separated
3. 3
   ДругоеThe organic phase is dried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated
6. 6
   ФильтрацияThe salt is filtered off
7. 7
   Другоеdried

Методика

A mixture of 3.58 parts of 1-(3-chloropropyl)-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one, 3.17 parts of 4-(4-chlorophenyl)-4-piperidinol, 5.3 parts of sodium carbonate, 0.2 parts of potassium iodide and 160 parts of 4-methyl-2-pentanone is stirred and refluxed for 24 hours with water-separator. After cooling, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is converted into the hydrochloride salt in methanol and 2-propanol. The salt is filtered off and dried, yielding 1.7 parts of 1-{3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl}-1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one hydrochloride; mp. 260.8° C.

Источник