Реакция #75140

Уравнение реакции

1-bromo-3-chloropropane

1,3-dihydro-1-(2-propenyl)-2H-benzimidazol-2-one

sodium hydroxide

→

1-(3-chloropropyl)-1,3-dihydro-3-(2-propenyl)-2H-benzimidazol-2-one

Выход 84.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   workup.STIRRINGUpon completion, stirring at 60° C.
3. 3
   ТемператураThe reaction mixture is cooled
4. 4
   Экстракцияthe product is extracted with trichloromethane
5. 5
   ДругоеThe extract is dried
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated

Методика

To a stirred and heated mixture of 17.5 parts of 1,3-dihydro-1-(2-propenyl)-2H-benzimidazol-2-one, 5-parts of N,N,N-triethylbenzenemethanaminium chloride and 150 parts of a sodium hydroxide solution 60% are added dropwise 20.5 parts of 1-bromo-3-chloropropane at 60° C. Upon completion, stirring at 60° C. is continued for 5 hours. The reaction mixture is cooled, water is added and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated, yielding 21 parts (84%) of 1-(3-chloropropyl)-1,3-dihydro-3-(2-propenyl)-2H-benzimidazol-2-one as a residue.

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