Реакция #7512

Уравнение реакции

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

potassium carbonate

sodium iodide

4-methoxybenzyl chloride

→

title compound

Выход 78.0%

Ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-methoxybenzyl)oxy]-5-pyrimidinecarboxylate

Выход 78.0%

Растворители

water

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Температураto cool to room temperature
2. 2
   ФильтрацияThe precipitated crystals were collected by filtration
3. 3
   Промывкаwashed several times with cold water and cold ether
4. 4
   Другоеdried

Методика

To a solution of ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (500 mg, 1.75 mmol) in N,N-dimethylformamide (10 mL) were added potassium carbonate (500 g, 4 mmol), sodium iodide (300 mg, 2 mmol) and 4-methoxybenzyl chloride (0.29 mL, 2 mmol), and the mixture was stirred at 80° C. for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether, and dried to give the title compound (550 mg, 78%).

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