Реакция #7497

Уравнение реакции

sodium hydride

ethyl 7-oxo-4-azepanecarboxylate

tert-butyl 2-bromobutanoate

→

diester

Выход 94.4%

ethyl 1-[1-(tert-butoxycarbonyl)propyl]-7-oxo-4-azepanecarboxylate

Выход 94.4%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураwith reflux condenser, magnetic stirrer
2. 2
   Концентрированиеconcentrated to dryness
3. 3
   workup.ADDITIONthe residue was poured on ice/water and neutralised with solid ammonium chloride
4. 4
   ЭкстракцияThe mixture was extracted three times with CH2Cl2
5. 5
   Сушкаthe combined organic phases were dried over magnesium sulfate
6. 6
   Фильтрацияfiltered
7. 7
   Концентрированиеconcentrated to dryness
8. 8
   ДругоеThe residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15)

Методика

In a 150 ml three necked flask fitted with reflux condenser, magnetic stirrer and dropping funnel under inert atmosphere, 5.09 g (27.5 mmoles, 1 eq) of ethyl 7-oxo-4-azepanecarboxylate 28 and 12.27 g (55 mmoles, 2 eq) of tert-butyl 2-bromobutanoate were dissolved in 70 ml of acetonitrile. The temperature was raised to 50° C. and 1.32 g (55 mmoles, 2 eq) of sodium hydride were added portionwise (exothermic). The mixture was stirred one more hour at 50° C. and concentrated to dryness, the residue was poured on ice/water and neutralised with solid ammonium chloride. The mixture was extracted three times with CH2Cl2, the combined organic phases were dried over magnesium sulfate, filtered and concentrated to dryness. The residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15) to give 8.5 g of pure diester 29, 69% yield.

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