Реакция #74634

Уравнение реакции

tert-butyl 2-[1-(diphenylmethyl)azetidin-3-yl]hydrazinecarboxylate

hydrogen chloride

→

title compound

Выход 85.0%

1-(diphenylmethyl)-3-hydrazinoazetidine dihydrochloride

Выход 85.0%

Растворители

1,4-dioxane

1,4-dioxane

Условия реакции

Обработка

1. 1
   КонцентрированиеThen the reaction mixture was concentrated in vacuo
2. 2
   Другоеthe residue was triturated with diethyl ether

Методика

To a stirred suspension of tert-butyl 2-[1-(diphenylmethyl)azetidin-3-yl]hydrazinecarboxylate (Preparation 691, 19.3 g, 54.6 mmol) in 1,4-dioxane (64 ml) was added 4M hydrogen chloride in 1,4-dioxane (290 ml) at 0° C. and stirred at room temperature for 4 hours. Then the reaction mixture was concentrated in vacuo and the residue was triturated with diethyl ether to give 15 g (85%) of the title compound as a white solid.

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