Реакция #74535

ord-ac3347557531442bb38b3e7c4c533cc4

Уравнение реакции

2-(2-aminopyridin-4-yl)-4-chlorophenol

CCOCN(c1ccncn1)S(=O)(=O)c1cc(Cl)c(F)cc1F

5-chloro-N-(ethoxymethyl)-2,4-difluoro-N-pyrimidin-4-ylbenzenesulfonamide

$CCOCn1cc/c(=N\S(=O)(=O)c2cc(Cl)c(F)cc2F)nc1$

5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide

$CCOCn1cc/c(=N\S(=O)(=O)c2cc(Cl)c(F)cc2F)nc1$

5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide

→

Nc1cc(-c2cc(Cl)ccc2Oc2cc(F)c(S(=O)(=O)Nc3ccncn3)cc2Cl)ccn1

title compound

4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyrimidin-4-ylbenzenesulfonamide

Реактанты

2-(2-aminopyridin-4-yl)-4-chlorophenol

5-chloro-N-(ethoxymethyl)-2,4-difluoro-N-pyrimidin-4-ylbenzenesulfonamide

$CCOCn1cc/c(=N\S(=O)(=O)c2cc(Cl)c(F)cc2F)nc1$

5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide

$CCOCn1cc/c(=N\S(=O)(=O)c2cc(Cl)c(F)cc2F)nc1$

5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide

Реагенты

Нет

Условия реакции

Подробные условия

See reaction.notes.procedure_details.

Методика

The title compound was prepared by analogy with the method used for Example 813 below using 5-chloro-N-(ethoxymethyl)-2,4-difluoro-N-pyrimidin-4-ylbenzenesulfonamide, 5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide and 5-chloro-N-[(4E)-1-(ethoxymethyl)pyrimidin-4(1H)-ylidene]-2,4-difluorobenzenesulfonamide, (Preparation 719) used as a mixture of three regioisomers and 2-(2-aminopyridin-4-yl)-4-chlorophenol (Preparation 721).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08541588B2uspto-grants-2013_09