Реакция #743614

Уравнение реакции

5-tert-Butyl-2,3-dihydro-1H-inden-1-ylamine

N-acetyl-(L)-leucine

→

title compound

(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураto cool to ambient temperature
2. 2
   ФильтрацияThe solids were filtered
3. 3
   Промывкаwashed with toluene
4. 4
   Температураto reflux
5. 5
   Температураto cool to ambient temperature
6. 6
   Фильтрацияthe solids were filtered
7. 7
   ДругоеThe solid was dried at 40° C. under reduced pressure

Методика

5-tert-Butyl-2,3-dihydro-1H-inden-1-ylamine (25.51 g, 93% potency), N-acetyl-(L)-leucine (23.34 g), and methanol (315 mL) were combined and heated at 65° C. for 1 hour. The solution was allowed to cool to ambient temperature. The solids were filtered and washed with toluene. The solid was then resuspended in methanol (125 mL) and brought to reflux. The solution was allowed to cool to ambient temperature and the solids were filtered. The solid was dried at 40° C. under reduced pressure to provide the title compound (98.7% ee).

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