Реакция #74352

ord-9d144667773442fc87b4fe299a459a75

Уравнение реакции

NC(=S)NC1(c2ccc(Cl)cc2)CCC1
N-[1-(4-chlorophenyl)cyclobutyl]thiourea
CCOC(=O)C(Br)C(C)C
ethyl 2-bromo-3-methylbutanoate
→
CC(C)C1SC(NC2(c3ccc(Cl)cc3)CCC2)=NC1=O
2-{[1-(4-Chlorophenyl)cyclobutyl]amino}-5-isopropyl-1,3-thiazol-4(5H)-one

Реактанты

NC(=S)NC1(c2ccc(Cl)cc2)CCC1
N-[1-(4-chlorophenyl)cyclobutyl]thiourea
CCOC(=O)C(Br)C(C)C
ethyl 2-bromo-3-methylbutanoate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеSynthesis

Методика

Synthesis was performed from N-[1-(4-chlorophenyl)cyclobutyl]thiourea and ethyl 2-bromo-3-methylbutanoate according to Method D.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08541592B2uspto-grants-2013_09