Реакция #742863

Уравнение реакции

NaOH

2-amino-3-cyano-4-hydroxy-6-(morpholin-4-yl)quinoline

phosphoryl chloride

→

2-Amino-3-cyano-4-chloro-6-(morpholin-4-yl)quinoline

Условия реакции

Обработка

1. 1
   ДругоеThe cooled reaction mixture
2. 2
   Фильтрацияthe precipitated material is filtered off
3. 3
   СушкаAfter drying 1.5 g of the title compound
4. 4
   Другоеis obtained

Методика

The mixture of 1.7 g of 2-amino-3-cyano-4-hydroxy-6-(morpholin-4-yl)quinoline and 3.4 mL of phosphoryl chloride is stirred at 120° C. for 4 hours. The cooled reaction mixture is poured onto 30 g of ice, the pH of the mixture is adjusted to 8 with 10% NaOH solution, and the precipitated material is filtered off. After drying 1.5 g of the title compound is obtained, m.p.: 206° C.

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