Реакция #742258

Уравнение реакции

3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid tert-butyl-dimethyl-silyl ester

oxalyl chloride

→

3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acryloyl chloride

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter complete addition the reaction mixture
2. 2
   ФильтрацияThe reaction mixture was filtered
3. 3
   Другоеevaporated to dryness
4. 4
   ТемператураThe solution was cooled in the refrigerator overnight
5. 5
   Фильтрацияfiltered
6. 6
   Другоеevaporated

Методика

To a 0° C. cold solution of 6.3 g of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid tert-butyl-dimethyl-silyl ester and 8 drops of DMF in 15 ml of CH2Cl2 was added dropwise 2.0 ml of oxalyl chloride. After complete addition the reaction mixture was allowed to warm to room temperature and stirring was continued for 60 h. The reaction mixture was filtered, evaporated to dryness and taken up in MTBE. The solution was cooled in the refrigerator overnight, filtered and evaporated to yield 4.4 g of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acryloyl chloride.

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