Реакция #742252

Уравнение реакции

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

dec-9-en-1-ol

→

colourless crystals

Выход 21.5%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid dec-9-enyl ester

Выход 21.5%

Растворители

ether

Условия реакции

Обработка

1. 1
   Другоеremoving the ethanol
2. 2
   Другоеformed
3. 3
   Температураthe reaction mixture was cooled
4. 4
   Промывкаwashed with brine
5. 5
   ДругоеThe organic phase was dried
6. 6
   Другоеevaporated to dryness
7. 7
   workup.DISTILLATIONThe resulting oil was Kugelrohr-distilled
8. 8
   Другоеcrystallized
9. 9
   Другоеrecrystallized

Методика

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

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