Реакция #742249

Уравнение реакции

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

Условия реакции

Обработка

1. 1
   ТемператураThen the reaction mixture was heated to reflux
2. 2
   ТемператураAfter refluxing for 31 hours the mixture
3. 3
   Температураwas cooled down
4. 4
   Другоеevaporated to dryness
5. 5
   ДругоеThe resulting dark oil was purified by chromatography
6. 6
   Другоеto yield a colourless oil

Методика

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

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