Реакция #742248

Уравнение реакции

(E)-3-(2-hydroxy-phenyl)-2-methyl-acrylic acid

citronellol

p-toluene-sulfonic acid

water

→

colourless oil

(E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 3,7 dimethyl-oct-6-enyl ester

Растворители

cyclohexane

hexane

Условия реакции

Обработка

1. 1
   ТемператураThen the reaction mixture was cooled down
2. 2
   Промывкаwashed
3. 3
   ДругоеThe organic phase was dried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated to dryness
6. 6
   ДругоеThe resulting yellow oil was purified by chromatography

Методика

A solution of 6 0 g of (E)-3-(2-hydroxy-phenyl)-2-methyl-acrylic acid, 5.3 g of citronellol and 1 g of p-toluene-sulfonic acid in 150 ml of cyclohexane was refluxed for 6.5 hours using a water separator. Then the reaction mixture was cooled down, diluted with hexane and washed to neutrality with saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by chromatography to yield 6.45 g of a colourless oil.

Источник