Реакция #73459

Уравнение реакции

7-chloro-6-fluoro-isoquinoline

m-chloro-perbenzoic acid

→

desired product 9

Выход 87.5%

7-Chloro-6-fluoro-isoquinoline 2-oxide

Выход 87.5%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   Промывкаwashed three times with saturated sodium bicarbonate solution
2. 2
   СушкаThe organic layer was dried over sodium sulphate
3. 3
   Другоеevaporated to dryness

Методика

50 g of 7-chloro-6-fluoro-isoquinoline (prepared according to WO 2007/012422) were dissolved in dichloromethane and cooled to 5° C. 69.6 g of m-chloro-perbenzoic acid (70%) were added portionwise. The mixture was stirred at room temperature. When conversion was complete, the mixture was diluted with 1.5 L of dichloromethane and washed three times with saturated sodium bicarbonate solution. The organic layer was dried over sodium sulphate and evaporated to dryness to give 47.6 g of the desired product 9. Rt=0.98 min (Method 5). Detected mass: 198.1 (M+H+).

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