Реакция #73294

Уравнение реакции

1,4-Dioxa-spiro[4.5]decan-8-one

lithium tetrahydroaluminate

→

1,4-Dioxaspiro[4.5]decan-8-ol

Растворители

ether

ether

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was then quenched with water and 1 N NaOH (0.5 mL of each) and
2. 2
   Фильтрацияthen filtered
3. 3
   ПромывкаThe filtered solid was washed with ether
4. 4
   Концентрированиеthe combined ether filtrate was concentrated
5. 5
   Другоеa rotary evaporator
6. 6
   Другоеto give the product

Методика

1,4-Dioxa-spiro[4.5]decan-8-one (2.00 g, 0.0128 mol) was dissolved in ether (50 mL) and the mixture was cooled to 0° C. To the reaction was added 1 M lithium tetrahydroaluminate in ether (7.0 mL) and this mixture was stirred at 0° C. for 2 hours at which time TLC analysis showed no starting material present. The reaction was then quenched with water and 1 N NaOH (0.5 mL of each) and then filtered. The filtered solid was washed with ether and the combined ether filtrate was concentrated using a rotary evaporator to give the product. NMR (CDCl3): 3.94 (m, 4H), 3.81 (m, 1H), 1.79-1.92 (m, 4H), 1.54-1.70 (m, 4H).

Источник