Реакция #732836

Уравнение реакции

sodium azide

triethylamine

2,3 dichlorophenylisocyanate

cyclohexylmethylamine

→

title compound

Выход 56.3%

N-(cyclohexylmethyl)-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine

Выход 56.3%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   Фильтрацияwas filtered through Celite
3. 3
   Концентрированиеthe organics concentrated in vacuo
4. 4
   ДругоеThe crude residue was purified by column chromatography (gradient elution; 25% ethyl acetate/hexanes to 35%)

Методика

To a solution of 2,3 dichlorophenylisocyanate (0.1 g, 0.49 mmol) in 5 mL anhydrous tetrahydrofuran was added cyclohexylmethylamine (0.1 g). The solution was stirred at room temperature for 2 h when mercury (II) acetate (0.13 g, 0.49 mmol), sodium azide (0.095 g, 1.47 mmol) and triethylamine (0.148 g, 1.47 mmol) were added. The resulting suspension was stirred at room temperature for 12 hours, at which time the precipitate was filtered through Celite and the organics concentrated in vacuo. The crude residue was purified by column chromatography (gradient elution; 25% ethyl acetate/hexanes to 35%) to give 0.09 g of the title compound as a sticky foam. MS (ESI/NH3) m/z 325 (M+H)+ 1H NMR (δ, DMSO-d6) 0.8-0.95 (m, 2H), 1.05-1.3 (m, 3H), 1.5-1.8 (m, 7H), 3.05-3.12 (t, 2H), 7.05-7.17 (t, 1H), 7.58-7.65 (m, 2H), 7.90-7.95 (d, 1H).

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