Реакция #73059

Уравнение реакции

tert-butyl 4 {[(3-amino-2-chloroquinolin-4-yl)amino]methyl}-4-hydroxypiperidine-1-carboxylate

triethylorthoformate

4-chloro-3-nitroquinoline

pyridine hydrochloride

triethylorthoformate

tert-butyl 4 {[(3-amino-2-chloroquinolin-4-yl)amino]methyl}-4-hydroxypiperidine-1-carboxylate

2,4-dichloro-3-nitroquinoline

→

tert-butyl 4-[(4-chloro-1H-imidazo[4,5-c]quinolin-1-yl)methyl]-4-hydroxypiperidine-1-carboxylate

Растворители

toluene

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 2 hours
3. 3
   Температураthe reaction mixture was heated for an additional hour
4. 4
   ДругоеThe small and larger scale reaction mixtures
5. 5
   Промывкаwashed with water (50 mL)
6. 6
   ЭкстракцияThe aqueous layer was extracted with dichloromethane (2×100 mL)
7. 7
   Концентрированиеconcentrated under reduced pressure
8. 8
   ДругоеThe residue was purified by column chromatography (silica gel eluting with a gradient of 0-10% methanol in ethyl acetate)

Методика

Under a nitrogen atmosphere, tert-butyl 4 {[(3-amino-2-chloroquinolin-4-yl)amino]methyl}-4-hydroxypiperidine-1-carboxylate (0.25 g, 0.61 mmol, prepared according to the general methods of Example 4 Parts A through D using 2,4-dichloro-3-nitroquinoline in lieu of 4-chloro-3-nitroquinoline in Part C), toluene (5 mL), pyridine hydrochloride (0.02 g), and triethylorthoformate (0.11 mL, 0.65 mmol) was heated at reflux for 2 hours. More triethylorthoformate (0.5 eq) was added and the reaction mixture was heated for an additional hour. The reaction was rerun in the same manner using 5.25 g of tert-butyl 4 {[(3-amino-2-chloroquinolin-4-yl)amino]methyl}-4-hydroxypiperidine-1-carboxylate. The small and larger scale reaction mixtures were combined and washed with water (50 mL). The aqueous layer was extracted with dichloromethane (2×100 mL). The organic layers were combined and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel eluting with a gradient of 0-10% methanol in ethyl acetate) to provide 4.08 g of tert-butyl 4-[(4-chloro-1H-imidazo[4,5-c]quinolin-1-yl)methyl]-4-hydroxypiperidine-1-carboxylate as a tan frothy solid.

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