Реакция #72983

Уравнение реакции

Water

cyclobutanone

nitromethane

sodium ethoxide

→

1-(nitromethyl)cyclobutanol

Выход 45.0%

Растворители

ethanol

ethanol

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture was extracted thrice with ethyl acetate
2. 2
   Промывкаwashed with water and brine
3. 3
   Сушкаdried over Na2SO4
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеThe volatiles were removed by distillation under vacuum

Методика

To a solution of cyclobutanone (10.0 g, 143 mmol) and nitromethane (12 mL) in ethanol (10 mL) was added sodium ethoxide in ethanol (2.67 M, 2.7 mL, 7.2 mmol). The mixture was stirred for 6 d at rt. Water was added and the mixture was extracted thrice with ethyl acetate. The organic phases were combined, washed with water and brine, dried over Na2SO4, filtered, and concentrated. The volatiles were removed by distillation under vacuum to provide 1-(nitromethyl)cyclobutanol as a yellow liquid (8.51 g, 45%).

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