Реакция #72925

Уравнение реакции

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

Выход 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

Выход 92.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was then filtered on celite
2. 2
   Другоеthe filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   Промывкаwashed with aqueous NaHCO3
5. 5
   СушкаThe solvent was dried over sodium sulfate
6. 6
   Другоеremoved under reduced pressure
7. 7
   Другоеto give

Методика

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

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