Реакция #72924

Уравнение реакции

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

Выход 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

Выход 83.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ТемператураThe resulting solution was refluxed for 6 hours
2. 2
   ДругоеThe solvent was then removed in vacuo
3. 3
   Другоеthe residue partitioned between dichloromethane and water
4. 4
   СушкаThe organic layer was dried over sodium sulfate
5. 5
   Другоеevaporated to dryness

Методика

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

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