Реакция #728853

Уравнение реакции

2-amino-6-(2-methoxypyrimidin-5-yl)-4-methyl-8-(tetrahydro-2H-pyran-4-yl)pyrido-[2,3-d]pyrimidin-7(8H)-one

TMSI

NH4OH

→

title compound

Выход 30.0%

2-Amino-6-(2-hydroxypyrimidin-5-yl)-4-methyl-8-(tetrahydro-2H-pyran-4-yl)pyrido[2,3-d]pyrimidin-7(8H)-one

Выход 30.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ТемператураAfter being cooled to room temperature
2. 2
   Концентрированиеconcentrated
3. 3
   ДругоеThe mixture was purified by analytical group (HPLC)

Методика

A mixture of 2-amino-6-(2-methoxypyrimidin-5-yl)-4-methyl-8-(tetrahydro-2H-pyran-4-yl)pyrido-[2,3-d]pyrimidin-7(8H)-one (42.2 mg, 0.115 mmol), TMSI (0.10 mL, 0.70 mmol), and dry acetonitrile (2.3 mL) was heated at 82° C. for 1 h. After being cooled to room temperature, the mixture was treated with 20% NH4OH solution and concentrated. The mixture was purified by analytical group (HPLC) to give the title compound (12 mg, 30%).

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