Реакция #7281

Уравнение реакции

4-hydroxymethyl-benzaldehyde

2-aminopyridine

acetic acid

sodium triacetoxyborohydride

→

title compound

Выход 74.0%

[4-(Pyridin-2-ylaminomethyl)-phenyl]-methanol

Выход 74.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Другоеone hour at 50° C., followed by purification of crude material

Методика

Using general procedure B: Reaction of 4-hydroxymethyl-benzaldehyde (1.01 g, 7.42 mmol), 2-aminopyridine (697 mg, 7.42 mmol), acetic acid (0.5 mL) and sodium triacetoxyborohydride (3.2 g, 14.8 mmol) in THF (20 mL) at room temperature under N2 for 40 min., then one hour at 50° C., followed by purification of crude material using chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2), afforded the title compound (1.17 g, 74%) as white foam.

Источник