Реакция #72799

Уравнение реакции

methyl 3-amino-5-morpholino-2-nitrobenzoate

→

desired product

Выход 80.1%

methyl 2,3-diamino-5-(4-morpholinyl)benzoate

Выход 80.1%

Растворители

MeOH

Условия реакции

Обработка

1. 1
   Другоеprepared
2. 2
   Другоеconsumption of starting material
3. 3
   Фильтрацияthe mixture was filtered
4. 4
   Концентрированиеthe filtrate was concentrated in-vacuo

Методика

A mixture of methyl 3-amino-5-morpholino-2-nitrobenzoate, prepared as described in Example 26, step c (19.2 g, 68.3 mmol) and Pd/C (1.9 g) in MeOH (500 mL) in an autoclave under an atmosphere of H2 (4 atm) were stirred at room temperature for 3 h, When TLC analysis indicated complete consumption of starting material, the mixture was filtered and the filtrate was concentrated in-vacuo to afford the desired product as a brown solid (13.9 g, 80.1%). 1H NMR (300 MHz, DMSO-d6): δ ppm 6.62 (d, 1H, J=2.4 Hz), 6.54 (d, 1H, J=2.4 Hz), 5.84 (s, 2H), 4.75 (s, 2H), 3.76 (s, 3H), 3.70 (t, 4H, J=4.8 Hz), 2.85 (t, 4H, 4.8 Hz). LC-MS: m/e=252.1 [M+1]+.

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