Реакция #725894

Уравнение реакции

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

Выход 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

Выход 55.6%

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Фильтрацияfiltered hot
4. 4
   Фильтрацияfiltered
5. 5
   Другоеdried

Методика

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

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