Реакция #725881

Уравнение реакции

Naproxen

→

2-(6-Hydroxynaphthalen-2-yl)propionic acid

Растворители

HBr

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 10 hours
2. 2
   workup.ADDITIONpoured onto ice water (3000 ml)
3. 3
   ФильтрацияCrude 5 was filtered
4. 4
   Другоеdried (380 grams, 81%)

Методика

A mixture of Naproxen (500 g, 2.774 mmol) and 48% HBr (1500 ml) was refluxed for 10 hours, poured onto ice water (3000 ml) and stirred for 30 minutes. Crude 5 was filtered, dried (380 grams, 81%) and used as such for next stage.

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