Реакция #724399

Уравнение реакции

methyl 2,5-dihydroxybenzoate

imidazole

t-butyldimethylsilyl chloride

→

methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   Экстракцияextract with water
2. 2
   СушкаDry the organic layer over MgSO4
3. 3
   Фильтрацияfilter
4. 4
   Другоеevaporate in vacuo

Методика

Combine methyl 2,5-dihydroxybenzoate (8.45 g, 50.2 mmol), imidazole (4.1 g, 60.3 mmol), and t-butyldimethylsilyl chloride (9.09 g, 60.3 mmol) in dichloromethane (100 mL). After 30 minutes, dilute the reaction mixture with dichloromethane (100 mL) and extract with water. Dry the organic layer over MgSO4, filter and evaporate in vacuo to give methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate.

Источник