Реакция #7240

Уравнение реакции

2-(hydroxymethyl)-3-methylpyridine

→

3-methylpyridine-2-carboxaldehyde

Выход 64.0%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   Фильтрацияthen filtered through celite
2. 2
   КонцентрированиеThe filtrate was concentrated

Методика

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

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