Реакция #722972

Уравнение реакции

dihydropyran

12-bromo-1-dodecanol

pyridinium p-toluenesulfonate

→

Tetrahydro-2-(12-bromododecanoxy)-2H pyran

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Промывкаwashed twice with water
2. 2
   Сушкаdried over anhydrous MgSO4
3. 3
   ДругоеThe dichloromethane is removed under reduced pressure
4. 4
   ДругоеIf necessary the resulting product is purified by chromatography on silica gel

Методика

To a solution of 12-bromo-1-dodecanol (1 mole) in dichloromethane containing pyridinium p-toluenesulfonate (P-TSA) is added dihydropyran (2 moles). The reaction mixture is stirred for 24 hours and then washed twice with water and dried over anhydrous MgSO4. The dichloromethane is removed under reduced pressure. If necessary the resulting product is purified by chromatography on silica gel.

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