Реакция #7202
ord-387a8ed2067c4b49ae065cb773dcae43
Уравнение реакции
1-bromo-3,3-dimethyl-butan-2-one
formamide
CH2Cl2 MeOH NH4OH
→
title compound
Выход 21.0%
5-tert-Butyl-1H-imidazole
Выход 21.0%
Реагенты
Нет
Условия реакции
Подробные условия
See reaction.notes.procedure_details.
Методика
Reaction of 1-bromo-3,3-dimethyl-butan-2-one (3.0 g, 16.80 mmol), and formamide (4.7 mL, 117.20 mmol), followed by chromatography (CH2Cl2/MeOH/NH4OH 94:3:3) gave the title compound (450 mg, 21%) as a yellow foam. 1H NMR (300 MHz, CDCl3) δ 1.29 (s, 9H), 6.77 (s, 1H), 7.57, (s, 1H). ES-MS m/z 125 (M+H).