Реакция #71996

Уравнение реакции

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride

2-chloropyridine

sodium carbonate

→

title compound

Выход 3.5%

cis(±)-4-Chloro-N-(3-ethoxy-1-pyridin-2-ylpiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide

Выход 3.5%

Растворители

DMF

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураthe suspension was heated
2. 2
   Другоеat 180° C.
3. 3
   Другоеfor 30 minutes
4. 4
   Промывкаwashed with water and brine
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   Концентрированиеconcentration under reduced pressure
7. 7
   Другоеthe residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=7/3→1/0)

Методика

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol), 2-chloropyridine (0.035 mL, 0.37 mmol) and sodium carbonate (157 mg, 1.48 mmol) were suspended in DMF (1 mL), and the suspension was heated using a microwave reactor at 180° C. for 30 minutes. The reaction solution was diluted with ethyl acetate, washed with water and brine, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=7/3→1/0) to obtain 3.9 mg of the title compound as a white amorphous solid (3%).

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