Реакция #7192

Уравнение реакции

acetophenone

acetic acid

bromine

→

title compound

Выход 41.0%

2-Bromo-1-phenyl-ethanone

Выход 41.0%

Условия реакции

Обработка

1. 1
   Другоеfollowed by recrystallisation from cold EtOAc/Hexane

Методика

Reaction of acetophenone (5.0 g, 42.00 mmol), acetic acid (2.4 mL, 42.00 mmol), and bromine (2.5 mL, 48.00 mmol) followed by recrystallisation from cold EtOAc/Hexane gave the title compound (3.4 g, 41%) as a white crystal. 1H NMR (300 MHz, CDCl3) δ 4.47 (s, 2H), 7.51 (d, 2H, J=7.5 Hz), 7.63 (t, 1H, J=7.5 Hz), 8.00 (d, 2H, J=7.2 Hz).

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