Реакция #718367

Уравнение реакции

POCl3

6,7-difluoro-4-hydroxyquinazoline

triethylamine

→

4-chloro-6,7-difluoroquinazoline

Выход 87.0%

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated in vacuo
2. 2
   ДругоеThe resulting sludge was triturated with EtOAc (2×100 mL)
3. 3
   Другоеthe combined decanted org layers
4. 4
   Другоеwere flushed through a plug of silica gel

Методика

To POCl3 (15 mL) was added 6,7-difluoro-4-hydroxyquinazoline (910 mg, 5 mmol) followed by triethylamine (700 uL, 5 mmol). The solution was then heated at 100° C. for 4 hours and concentrated in vacuo. The resulting sludge was triturated with EtOAc (2×100 mL), and the combined decanted org layers were flushed through a plug of silica gel to give 4-chloro-6,7-difluoroquinazoline (870 mg, 4.35 mmol, 87%). LC-MS (ESI) m/z 201 (M+H)+.

Источник