Реакция #71630

ord-2c4dc3952e974ba3ba1a101c341b54fb

Уравнение реакции

N#Cc1cc(Br)ccc1F
5-bromo-2-fluorobenzonitrile
CC(C)(C)OC(=O)N1CCC(N)CC1
1,1-dimethylethyl 4-amino-1-piperidinecarboxylate
→
CC(C)(C)OC(=O)N1CCC(Nc2ccc(F)c(C#N)c2)CC1
title compound
CC(C)(C)OC(=O)N1CCC(Nc2ccc(F)c(C#N)c2)CC1
1,1-Dimethylethyl 4-[(3-cyano-4-fluorophenyl)amino]-1-piperidinecarboxylate

Реактанты

N#Cc1cc(Br)ccc1F
5-bromo-2-fluorobenzonitrile
CC(C)(C)OC(=O)N1CCC(N)CC1
1,1-dimethylethyl 4-amino-1-piperidinecarboxylate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound was prepared from 5-bromo-2-fluorobenzonitrile and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate using a method similar to that described for D10a.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08536182B2uspto-grants-2013_09