Реакция #71558

Уравнение реакции

4-nitrophenol

triethylamine

ethyl acetate

water

→

butyl 4-nitrophenyl carbonate

Растворители

tetrahydrofuran

butyl chloroformate

Условия реакции

Обработка

1. 1
   Температураunder cooling on ice
2. 2
   ДругоеThe organic layer was separated
3. 3
   Промывкаwashed with a saturated sodium chloride aqueous solution
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   ДругоеAfter removing the solvent
6. 6
   Другоеby evaporation under reduced pressure

Методика

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

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