Реакция #712968

Уравнение реакции

2-amino-4-fluorobenzamide

diethyl oxalate

→

ethyl 7-fluoro-4-hydroxyquinazoline-2-carboxylate

Выход 22.0%

Растворители

AcOH

Условия реакции

Обработка

1. 1
   ФильтрацияThe solid was collected by filtration
2. 2
   Другоеdried under reduced pressure

Методика

A solution of 2-amino-4-fluorobenzamide (750 mg, 4.40 mmol), diethyl oxalate (20 mL), and AcOH (8 mL) was stirred at 140° C. for 16 h. The solid was collected by filtration and dried under reduced pressure to afford ethyl 7-fluoro-4-hydroxyquinazoline-2-carboxylate as a solid (235 mg, 22%). 1H NMR (300 MHz, DMSO-d6) δ 1.36 (t, J=7.08 Hz, 2H), 4.39 (q, J=7.08 Hz, 2H), 7.52 (m, 1H), 7.67 (m, 1H), 8.25 (m, 1H), 11.97 (br s, 1H), 12.77 (br s, 1H).

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