Реакция #71268

Уравнение реакции

(R)-5-bromo-2,3-dihydro-1H-inden-2-amine((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

potassium carbonate

benzyl chloroformate

→

(R)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-ylcarbamate

Выход 89.5%

Растворители

water

ethylacetate

EtOAc

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONadded
2. 2
   ТемператураThe mixture was cooled in an ice bath
3. 3
   Другоеcame to room temperature
4. 4
   ДругоеThe crude reaction mixture
5. 5
   workup.ADDITIONthe phases mixed
6. 6
   Другоеseparated
7. 7
   ЭкстракцияThe aqueous layer was further extracted with EtOAc (×2)
8. 8
   ДругоеCombined organics were dried
9. 9
   Концентрированиеconcentrated before crystallisation of the product from ethylacetate/heptane mixture

Методика

(R)-5-bromo-2,3-dihydro-1H-inden-2-amine((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (12.56 mmol, 5.58 g) was dissolved in EtOAc (30 mL)/water (30 mL) and potassium carbonate (37.7 mmol, 5.21 g) added. The mixture was cooled in an ice bath and benzyl chloroformate (13.81 mmol, 1.964 mL, 2.356 g) added dropwise. Stirring was continued overnight during which time the reaction came to room temperature. The crude reaction mixture was diluted with water and ethylacetate and the phases mixed and separated. The aqueous layer was further extracted with EtOAc (×2). Combined organics were dried and concentrated before crystallisation of the product from ethylacetate/heptane mixture to give (R)-benzyl 5-bromo-2,3-dihydro-1H-inden-2-ylcarbamate as colourless needles (3.89 g, 89%). 1H NMR (400 MHz, CDCl3) δ 2.79 (m, 2H) 3.26 (m, 2H) 4.53 (bm, 1H) 4.93 (bm, 1H) 5.10 (bs, 2H) 7.07 (m, 1H) 7.26-7.37 (m, 7H)

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