Реакция #710542

Уравнение реакции

HCl

isobutylamine

4-bromobenzenesulfonyl chloride

pyridine

→

4-bromo-N-isobutyl-benzenesulfonamide

Выход 87.3%

Растворители

DCM

Условия реакции

Обработка

1. 1
   Экстракцияthe reaction extracted with DCM
2. 2
   Фильтрацияfiltered through a phase separator
3. 3
   Концентрированиеconcentrated

Методика

To a solution of 4-bromobenzenesulfonyl chloride (2 g, 7.8 mmol) in DCM (40 mL) was added pyridine (1.9 mL, 23.5 mmol) followed by isobutylamine (1.56 mL, 15.7 mmol) and the reaction was stirred at room temperature for 16 hours. 1M aqueous HCl was added and the reaction extracted with DCM, filtered through a phase separator and concentrated to give 4-bromo-N-isobutyl-benzenesulfonamide (1.99 g). LCMS (m/z, Method A) ES+ 294[M+1]+

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