Реакция #710526

Уравнение реакции

Compound I

2-(1,3-benzodioxol-5-yl)-2-methyl propanal

NH2OH

pyridine

→

Compound J

Выход 96.0%

2-(1,3-benzodioxol-5-yl)-2-methyl propanal oxime

Выход 96.0%

Растворители

ethanol

HCl

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture was evaporated to dryness
2. 2
   workup.ADDITIONadded 10 mL of ethyl acetate
3. 3
   ПромывкаThe organic layer was washed with distilled water
4. 4
   Сушкаdried over anhydrous sodium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Другоеevaporated
7. 7
   ДругоеThe crude reaction mixture
8. 8
   Другоеwas purified over silica gel column

Методика

To a solution of Compound I (511 mg, 2.66 mmol) in ethanol (1 mL), HCl.NH2OH (277 mg, 4.00 mmol) and pyridine (2.2 mL, 26.58 mmol) were added and it was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated to dryness and added 10 mL of ethyl acetate. The organic layer was washed with distilled water, dried over anhydrous sodium sulfate, filtered and evaporated. The crude reaction mixture was purified over silica gel column using 5:1 petroleum ether-ethyl acetate as solvent to afford Compound J (528 mg, 96%) as a white foam.

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