Реакция #710503

ord-09beeee2505841458329c4dc2d85ed28

Уравнение реакции

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

Реактанты

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

Реагенты

Нет

Растворители

O
water
O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеreaction
  2. 2
    Другоеfor the reaction
  3. 3
    ДругоеCarbon dioxide is evaporated rapidly
  4. 4
    Другоеwater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    ДругоеThe product is then dried
  7. 7
    Другоеcrushed to fine particles
  8. 8
    Другоеto produce an active composition suitable for formulation into the pharmacological formulations of this invention

Методика

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09301935B2uspto-grants-2016_04