Реакция #710474

Уравнение реакции

2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

2-chloro-5-chloromethyl pyridine

potassium carbonate

→

N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2-difluoroacetamide

Растворители

acetonitrile

acetonitrile

Условия реакции

Обработка

1. 1
   workup.ADDITIONadded
2. 2
   Температураthe resulting mixture was heated
3. 3
   Температураrefluxed for 140 minutes
4. 4
   Другоеwas returned to room temperature
5. 5
   Фильтрацияto filter off insoluble materials
6. 6
   Концентрированиеthe filtrate was concentrated under reduced pressure
7. 7
   workup.ADDITIONEther was added
8. 8
   Другоеto precipitate a solid
9. 9
   Другоеthus the solid was collected
10. 10
    Другоеdried well
11. 11
    Другоеto obtain the subject material
12. 12
    ДругоеAmount obtained 63 mg (yield 37%)

Методика

100 mg (0.58 mmol) of the 2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the aforementioned method was dissolved in 10 ml of anhydrous acetonitrile, 94 mg (0.58 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 5 ml of anhydrous acetonitrile and added thereto, and subsequently, 84 mg (0.63 mmol) of potassium carbonate was added thereto and the resulting mixture was heated and refluxed for 140 minutes. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials, and the filtrate was concentrated under reduced pressure. Ether was added thereto to precipitate a solid, and thus the solid was collected and dried well to obtain the subject material. Amount obtained 63 mg (yield 37%).

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