Реакция #710467

Уравнение реакции

2-chloro-3-fluoro-5-methyl pyridine

N-bromosuccinimide

→

5-(bromomethyl)-2-chloro-3-fluoropyridine

Выход 51.0%

Растворители

carbon tetrachloride

Условия реакции

Обработка

1. 1
   Температураthe resulting mixture was heated
2. 2
   Температураrefluxed overnight
3. 3
   Другоеwas returned to room temperature
4. 4
   Концентрированиеconcentrated under reduced pressure
5. 5
   Другоеpurified by silica gel column chromatography (hexane:ethyl acetate=19:1)

Методика

4.00 g (27.6 mmol) of 2-chloro-3-fluoro-5-methyl pyridine was dissolved in 80 ml of carbon tetrachloride, 7.37 g (41.4 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed overnight. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 3.06 g (yield 51%) of 5-(bromomethyl)-2-chloro-3-fluoropyridine.

Источник