Реакция #708951

Уравнение реакции

hexadecanesulfonylchloride

7-dimethylaminoheptylamine

→

title compound

Выход 33.6%

N-[7-(dimethylamino)heptyl]-1-hexadecanesulfonamide

Выход 33.6%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture is evaporated under reduced pressure (<30° C.)
2. 2
   Другоеdried in vacuo
3. 3
   Другоеchromatographed on silica gel in the system CH2Cl2 :CH3OH:NH4OH (65:25:4) and fractions 47-52 having Rf 0.9 on TLC S.G
4. 4
   Другоеevaporated under reduced pressure <30° C.
5. 5
   Другоеdried in vacuo

Методика

650 mg (2 meq) of hexadecanesulfonylchloride are added dropwise to 744 mg (4 meq) of 7-dimethylaminoheptylamine stirring in tetrahydrofuran at 0° C. The reaction mixture is evaporated under reduced pressure (<30° C.) dried in vacuo, and chromatographed on silica gel in the system CH2Cl2 :CH3OH:NH4OH (65:25:4) and fractions 47-52 having Rf 0.9 on TLC S.G. CH2Cl2 :CH3OH:NH4OH are combined, evaporated under reduced pressure <30° C. and dried in vacuo to yield 300 mg of title compound having a m.p. of 56°-57.5° C. uncorr.

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