Реакция #70640

Уравнение реакции

N-tert-butyl-5-cyano-2-fluoro-benzenesulfonamide

→

5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

Выход 90.0%

Растворители

HCl EtOH

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture was filtered through a pad of diatomaceous earth
2. 2
   Промывкаwashed with MeOH
3. 3
   Концентрированиеconcentrated to about 3 ml
4. 4
   workup.ADDITIONThe residue was diluted with H2O

Методика

A mixture of N-tert-butyl-5-cyano-2-fluoro-benzenesulfonamide (0.3 g) and Pd/C (50 mg) in 1N HCl/EtOH (1 ml 1N HCl in 10 ml EtOH) was stirred under H2 for 2 hours. The reaction mixture was filtered through a pad of diatomaceous earth, washed with MeOH and concentrated to about 3 ml. The residue was diluted with H2O and lyophilized to give 5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide (0.27 g, 90% yield) as a white powder.

Источник